Tag: dofetilide cimetidine interaction
Dofetilide and Cimetidine: Why This Drug Pair Can Trigger Deadly Heart Rhythms
- Laura Ledas
- Dec, 19 2025
Dofetilide and cimetidine together can cause deadly heart rhythms. This well-documented interaction raises dofetilide levels by up to 100%, triggering QT prolongation and torsades de pointes. Safe alternatives exist - and this combo is absolutely contraindicated.
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